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Picture of Rabbit Anti-Mouse F4/80 Monoclonal Antibody (Clone SP115)

Rabbit Anti-Mouse F4/80 Monoclonal Antibody (Clone SP115)

For research use only. Not for use in diagnostics.

Product No. Pack Size
06973264001
0.1 mL

Product No. Pack Size
06973302001
1.0 mL




Mouse EGF-like module-containing mucin-like hormone receptor-like 1 (EMR1) or cell surface glycoprotein F4/80 is a cell surface glycoprotein and a member of the EGF TM7 family of proteins. It shares 68% overall amino acid identity with human EGF-module-containing-mucin-like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ regulatory T cells. **Please contact us for availability**

Figure above:
Mouse Liver stained with anti-F4/80 antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.


IHC Performance


Mouse Liver stained with anti-F4-80 antibody

Human Colon stained with anti-F4-80 antibody

Human Esophagus stained with anti-F4-80 antibody

Mouse Liver stained with anti-F4-80 antibody

Mouse Liver stained with anti-F4-80 antibody

Human Colon stained with anti-F4-80 antibody

Human Esophagus stained with anti-F4-80 antibody

Mouse Liver stained with anti-F4-80 antibody


Product Details:


Technology

Rabbit Monoclonal

Clone Name

SP115

Application

IHC-P

Species Reactivity

 

   Tested

Hu

   Predicted by homology

Rt

Isotype

Rabbit IgG

Immunogen

Synthetic peptide derived from N-terminus of mouse F4/80 protein.

Cellular Localization

Membrane

Control Tissue

Human Lung, Fresh Cut Mouse Liver

Regulatory Rating

Research Use Only (RUO)

Entrez

13733

Storage Requirement

2-8°C

Target Molecular Weight

160 kDa

Formulation

Refer to Data Sheet

Product No: 06973264001
Product No: 06973302001

Rabbit Anti-Mouse F4/80 Monoclonal Antibody (Clone SP115)

Instructions for Use (PDF, 51.55 KB)

Discovery XT Staining Protocol for F4/80 on Mouse Liver

Discovery-XT-Staining-Protocol (PDF)

Discovery XT Staining Protocol for F4/80 on Human Lung

Discovery-XT-Staining-Protocol (PDF)
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