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Rabbit Anti-Human URI Monoclonal Antibody (Clone SP215)

For research use only. Not for use in diagnostics.

Product No. Pack Size
07070314001
0.1 mL

Product No. Pack Size
07070969001
1.0 mL


Unconventional prefoldin RPB5 interactor (URI) is an oncogene required for the survival of some human carcinomas and is often amplified and over-expressed in subsets of carcinomas from ovary, breast, stomach, and lung. Activation of URI contributes an important mechanism for activating mitochondrial S6K1-BAD signaling and promoting cell survival through disabling PP1γ-dependent negative feedback inhibition. URI can negatively modulate RNA polymerase II subunit 5 (RPB5) and mediates resistance of cells to cisplatin.

Figure above:
Human ovarian adenocarcinoma stained with anti-URI antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.


IHC Performance


Human Ovarian adenocarcinoma stained with anti-URI antibody

Human Ovarian adenocarcinoma stained with anti-URI antibody



Flow Cytometric Analysis


Flow cytometric analysis of rabbit anti-URI (SP215) antibody in 293 (green) compare to negative control of rabbit IgG (blue)

Flow cytometric analysis of rabbit anti-URI (SP215) antibody in 293 (green) compare to negative control of rabbit IgG (blue)


Product Details:


Technology

Rabbit Monoclonal

Clone Name

SP215

Application

IHC-P, FACS

Species Reactivity

 

   Tested

Hu

   Predicted by homology

Bv, Ms

Isotype

Rabbit IgG

Immunogen

Synthetic peptide derived from the C-terminus of the human URI protein.

Cellular Localization

Cytoplasm, Nucleus

Control Tissue

Ovarian Carcinoma

Regulatory Rating

Research Use Only (RUO)

Entrez

8725

Storage Requirement

2-8°C

Target Molecular Weight

57 kDa

Formulation

Refer to Data Sheet

Product No: 07070314001
Product No: 07070969001

Rabbit Anti-Human URI Monoclonal Antibody (Clone SP215)

Instructions for Use (PDF, 161.76 KB)
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