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Rabbit Anti-Human Tau Monoclonal Antibody (Clone SP70)

For research use only. Not for use in diagnostics.

Product No. Pack Size
06971571001
0.1 mL

Product No. Pack Size
06971601001
1.0 mL



Tau is a neuronal microtubule associated protein found predominantly on axons. The function of rau is to promote tubulin polymerization and stabilize microtubules, but it also serves to link certain signaling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate tau. Alternate splicing of tau mRNA and differential phosphorylation contributes to the heterogeneity of Tau. **Please contact us for availability**

Figure above:
Human Breast Carcinoma stained with anti-Tau (Neuronal Marker) antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.


IHC Performance


Human Breast stained with anti-Tau antibody

Human Breast Adenocarcinoma stained with anti-Tau antibody

Human Prostate Adenocarcinoma stained with anti-Tau antibody

Human Renal Cell Carcinoma stained with anti-Tau antibody

Human Breast stained with anti-Tau antibody

Human Breast Adenocarcinoma stained with anti-Tau antibody

Human Prostate Adenocarcinoma stained with anti-Tau antibody

Human Renal Cell Carcinoma stained with anti-Tau antibody

Human Pancreas stained with anti-Tau antibody

Human Colon stained with anti-Tau antibody

Human Small Intestine stained with anti-Tau antibody

Human Bladder stained with anti-Tau antibody

Human Pancreas stained with anti-Tau antibody

Human Colon stained with anti-Tau antibody

Human Small Intestine stained with anti-Tau antibody

Human Bladder stained with anti-Tau antibody

Human Spinal Cord stained with anti-Tau antibody

Human Cerebellum stained with anti-Tau antibody

Human Cerebral Cortex stained with anti-Tau antibody

Human Spinal Cord stained with anti-Tau antibody

Human Cerebellum stained with anti-Tau antibody

Human Cerebral Cortex stained with anti-Tau antibody



Flow Cytometric Analysis

 


Flow cytometric analysis of rabbit anti-Tau (Neuronal Marker) (SP70) antibody in SH-SY5Y (green) compare to negative control of rabbit IgG (blue)
Flow cytometric analysis of rabbit anti-Tau (Neuronal Marker) (SP70) antibody in SH-SY5Y (green) compare to negative control of rabbit IgG (blue)



Product Details:


Technology

Rabbit Monoclonal

Clone Name

SP70

Application

IHC-P, FACS

Species Reactivity

 

   Tested

Hu

   Predicted by homology

 

Isotype

Rabbit IgG

Immunogen

Synthetic peptide corresponding to N-terminus of human tau protein.

Cellular Localization

Cytoplasm

Control Tissue

Breast Carcinoma

Regulatory Rating

Research Use Only (RUO)

Entrez

4137

Storage Requirement

2-8°C

Target Molecular Weight

45-68 kDa

Formulation

Refer to Data Sheet

Product No: 06971571001
Product No: 06971601001

Rabbit Anti-Human Tau Monoclonal Antibody (Clone SP70)

Instructions for Use (PDF, 74.71 KB)
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