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Rabbit Anti-Human pI3KCA Monoclonal Antibody (Clone SP139)

For research use only. Not for use in diagnostics.

Product No. Pack Size
06974198001
0.1 mL

Product No. Pack Size
06974228001
1.0 mL


Phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3KCA) is encoded by the PIK3CA oncogene and catalyzes the production of phosphatidylinositol-3, 4, 5- triphosphate (PIP3). PIP3 activates downstream signaling components such as protein kinase AKT and promotes cell growth and survival. The PIK3CA oncogene is one of the two most frequently mutated oncogenes in human cancer. PI3KCA mutations are associated with colorectal cancer, breast cancer, ovarian cancer, endometrial carcinoma and hepatocellular carcinoma.

Figure above:
Human Breast Ductal Carcinoma stained with anti-PI3KCA antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.


IHC Performance


Human Bladder Transitional Cell Carcinoma stained with anti-PI3KCA antibody

Human Breast Ductal Carcinoma stained with anti-PI3KCA antibody

Human Colon Adenocarcinoma stained with anti-PI3KCA antibody

Human Prostate Adenocarcinoma stained with anti-PI3KCA antibody

Human Bladder Transitional Cell Carcinoma stained with anti-PI3KCA antibody

Human Breast Ductal Carcinoma stained with anti-PI3KCA antibody

Human Colon Adenocarcinoma stained with anti-PI3KCA antibody

Human Prostate Adenocarcinoma stained with anti-PI3KCA antibody

Human Skin Squamous Cell Carcinoma stained with anti-PI3KCA antibody

Human Skin stained with anti-PI3KCA antibody

Human Stomach Adenocarcinoma stained with anti-PI3KCA antibody

Human Stomach stained with anti-PI3KCA antibody

Human Skin Squamous Cell Carcinoma stained with anti-PI3KCA antibody

Human Skin stained with anti-PI3KCA antibody

Human Stomach Adenocarcinoma stained with anti-PI3KCA antibody

Human Stomach stained with anti-PI3KCA antibody


Product Details:


Technology

Rabbit Monoclonal

Clone Name

SP139

Application

IHC-P

Species Reactivity

 

   Tested

Hu

   Predicted by homology

Bv, Ck, Ms

Isotype

Rabbit IgG

Immunogen

Synthetic peptide in the internal region of the human pI3KCA protein.

Cellular Localization

Membrane

Control Tissue

Breast Carcinoma

Regulatory Rating

Research Use Only (RUO)

Entrez

5290

Storage Requirement

2-8°C

Target Molecular Weight

110-124 kDa

Formulation

Refer to Data Sheet

Product No: 06974198001
Product No: 06974228001

Rabbit Anti-Human pI3KCA Monoclonal Antibody (Clone SP139)

Instructions for Use (PDF, 56.83 KB)
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