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Rabbit Anti-Human PD-L1/CD274 Monoclonal Antibody (Clone SP142)

For research use only. Not for use in diagnostics.

Product No. Pack Size
07309457001
0.1 mL

Product No. Pack Size
07309554001
1.0 mL




Programmed cell death ligand 1 (PD-L1) also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1) is a type 1 transmembrane protein involved in the regulation of cellular and humoral immune responses. The interaction of PD-L1 with its receptor PD-1 provides both stimulatory and inhibitory signals in regulating T cell activation and tolerance during pregnancy,tissue allografts, autoimmune disease and malignant transformation. PD-L1 is mainly expressed in antigen presenting cells, activated T and B cells, placenta, and some tumors such as melanoma, diffuse large B-cell lymphoma, and carcinoma of the lung, colon, and rectum.

Figure above:
Human placenta stained with anti-PD-L1 antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.



Human lung squamous cell carcinoma stained with anti-PD-L1 antibody

Human Hodgkin's lymphoma stained with anti-PD-L1 antibody

Human placenta stained with anti-PD-L1 antibody

Human tonsil stained with anti-PD-L1 antibody

Human lung squamous cell carcinoma stained with anti-PD-L1 antibody

Human Hodgkin's lymphoma stained with anti-PD-L1 antibody

Human placenta stained with anti-PD-L1 antibody

Human tonsil stained with anti-PD-L1 antibody

Human cervical squamous cell carcinoma stained with anti-PD-L1 antibody

Human pancreatic adenocarcinoma stained with anti-PD-L1 antibody

Human skin squamous cell carcinoma stained with anti-PD-L1 antibody

Human prostate adenocarcinoma stained with anti-PD-L1 antibody

Human cervical squamous cell carcinoma stained with anti-PD-L1 antibody

Human pancreatic adenocarcinoma stained with anti-PD-L1 antibody

Human skin squamous cell carcinoma stained with anti-PD-L1 antibody

Human prostate adenocarcinoma stained with anti-PD-L1 antibody


Product Details:


Technology

Rabbit Monoclonal

Clone Name

SP124

Application

IHC-P,

Species Reactivity

 

   Tested

Hu

   Predicted by homology

N/A

Isotype

Rabbit IgG

Immunogen

Synthetic peptide derived from the C-terminus of human PD-L1 protein.

Cellular Localization

Membrane

Control Tissue

Placenta

Regulatory Rating

Research Use Only (RUO)

Entrez

29126

Storage Requirement

2-8°C

Target Molecular Weight

42 kDa

Formulation

Refer to Data Sheet

Product No: 07309457001
Product No: 07309554001

Rabbit Anti-Human PD-L1/CD274 Monoclonal Antibody (Clone SP142)

Instructions for Use (PDF, 57.3 KB)
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