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Rabbit Anti-Human MSH2 Monoclonal Antibody (Clone SP46)

For research use only. Not for use in diagnostics.

Product No. Pack Size
05497035001
0.1 mL

Product No. Pack Size
05497051001
1.0 mL



MSH2 is involved in DNA repair as a mismatch repair protein, and mutations of MSH2 are found in approximately 50% of inherited non polyposis colorectal carcinoma (HNPCC) (Lynch syndrome) cases. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the western world.

Figure above:
Human Colon Carcinoma stained with anti-MSH2 antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.


IHC Performance


Human Colon Carcinoma stained with anti-MSH2 antibody

Human Tonsil stained with anti-MSH2 antibody

Human Thyroid stained with anti-MSH2 antibody

Human Skin stained with anti-MSH2 antibody

Human Colon Carcinoma stained with anti-MSH2 antibody

Human Tonsil stained with anti-MSH2 antibody

Human Thyroid stained with anti-MSH2 antibody

Human Skin stained with anti-MSH2 antibody

Human Prostate stained with anti-MSH2 antibody

Human Placenta stained with anti-MSH2 antibody

Human Lung stained with anti-MSH2 antibody

Human Endometrium stained with anti-MSH2 antibody

Human Prostate stained with anti-MSH2 antibody

Human Placenta stained with anti-MSH2 antibody

Human Lung stained with anti-MSH2 antibody

Human Endometrium stained with anti-MSH2 antibody

Human Colon stained with anti-MSH2 antibody

Human Colon Adenocarcinoma stained with anti-MSH2 antibody

Human Cervix stained with anti-MSH2 antibody

Human Colon stained with anti-MSH2 antibody

Human Colon Adenocarcinoma stained with anti-MSH2 antibody

Human Cervix stained with anti-MSH2 antibody



Flow Cytometric Analysis


Flow cytometric analysis of rabbit anti-MSH2 (SP46) antibody in HeLa (green) compare to negative control of rabbit IgG (blue)
Flow cytometric analysis of rabbit anti-MSH2 (SP46) antibody in HeLa (green) compare to negative control of rabbit IgG (blue)



Product Details:


Technology

Rabbit Monoclonal

Clone Name

SP46

Application

IHC-P, FACS

Species Reactivity

 

   Tested

Hu

   Predicted by homology

Bv, Ck, Dg, Ms, Pg, Rt

Isotype

Rabbit IgG

Immunogen

Synthetic peptide corresponding to internal region of human MSH2.

Cellular Localization

Nucleus

Control Tissue

Colon Carcinoma

Regulatory Rating

Research Use Only (RUO)

Entrez

4436

Storage Requirement

2-8°C

Target Molecular Weight

100 kDa (Predicted)

Formulation

Refer to Data Sheet

Product No: 05497035001
Product No: 05497051001

Rabbit Anti-Human MSH2 Monoclonal Antibody (Clone SP46)

Instructions for Use (PDF, 78.23 KB)
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