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Picture of Rabbit Anti-Human Cadherin-N/N-Cadherin Monoclonal Antibody (Clone SP90)

Rabbit Anti-Human Cadherin-N/N-Cadherin Monoclonal Antibody (Clone SP90)

For research use only. Not for use in diagnostics.

Product No. Pack Size
06972349001
0.1 mL

Product No. Pack Size
06972373001
1.0 mL




N-cadherin is a 140kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. The function of N-cadherin is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of β-catenin. This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. **Please contact us for availability**

Figure above:
Human Mesothelioma stained with anti-Cadherin-N/N-Cadherin antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.


IHC Performance


Human Mesothelioma stained with anti-Cadherin-N/N-Cadherin antibody

Human Mesothelioma stained with anti-N-Cadherin antibody

Human Liver stained with anti-N-Cadherin antibody

Human Adrenal Gland stained with anti-N-Cadherin antibody

Human Mesothelioma stained with anti-Cadherin-N/N-Cadherin antibody

Human Mesothelioma stained with anti-N-Cadherin antibody

Human Liver stained with anti-N-Cadherin antibody

Human Adrenal Gland stained with anti-N-Cadherin antibody

Human Fallopian Tubes stained with anti-N-Cadherin antibody

Human Renal Cell Carcinoma stained with anti-N-Cadherin antibody

Human Stomach stained with anti-N-Cadherin antibody

Human Fallopian Tubes stained with anti-N-Cadherin antibody

Human Renal Cell Carcinoma stained with anti-N-Cadherin antibody

Human Stomach stained with anti-N-Cadherin antibody



Flow Cytometric Analysis


Flow cytometric analysis of rabbit anti-Cadherin-N (SP90) antibody in HeLa (green) compare to negative control of rabbit IgG (blue)
Flow cytometric analysis of rabbit anti-Cadherin-N (SP90) antibody in HeLa (green) compare to negative control of rabbit IgG (blue)


Product Details:


Technology

Rabbit Monoclonal

Clone Name

SP90

Application

IHC-P, FACS

Species Reactivity

 

   Tested

Hu

   Predicted by homology

Bv, Ms, Rt

Isotype

Rabbit IgG

Immunogen

Synthetic peptide corresponding to C-terminus of human cadherin-N protein.

Cellular Localization

Membrane

Control Tissue

Mesothelioma

Regulatory Rating

Research Use Only (RUO)

Entrez

1000

Storage Requirement

2-8°C

Target Molecular Weight

140 kDa

Formulation

Refer to Data Sheet

Product No: 06972349001
Product No: 06972373001

Rabbit Anti-Human Cadherin-N/N-Cadherin Monoclonal Antibody (Clone SP90)

Instructions for Use (PDF, 164.61 KB)
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