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Picture of Rabbit Anti-Human Aurora Kinase A/B/C Monoclonal Antibody (Clone SP201)

Rabbit Anti-Human Aurora Kinase A/B/C Monoclonal Antibody (Clone SP201)

For research use only. Not for use in diagnostics.

Product No. Pack Size
07068654001
0.1 mL

Product No. Pack Size
07068689001
1.0 mL




Aurora kinases are highly conserved serine/threonine kinases in eukaryotes, involved in many processes during cell division. Three aurora kinases have been identified in humans and designated as Aurora-A, -B, and -C. They mostly consist of two domains: a regulatory domain in the NH2 terminus and a catalytic domain in the COOH terminus. Aurora A regulates centrosome function during M phase and is required for initial activation of CDK1 at centrosomes and phosphorylates numerous target proteins. Over-expression of Aurora-A or -B protein can lead to aneuploid cells and is frequently observed in various human cancers such as prostate, breast, and esophageal cancers.

Figure above:
Human prostate cancer stained with anti-Aurora kinase A/B/C antibody

Contents

Rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.


IHC Performance


Human Prostate stained with anti-Aurora A/B/C antibody

Human Cervical SCCa stained with anti-Aurora A/B/C antibody

Human Colon stained with anti-Aurora A/B/C antibody

Human Testis stained with anti-Aurora A/B/C antibody

Human Prostate stained with anti-Aurora A/B/C antibody

Human Cervical SCCa stained with anti-Aurora A/B/C antibody

Human Colon stained with anti-Aurora A/B/C antibody

Human Testis stained with anti-Aurora A/B/C antibody

Human Uterus stained with anti-Aurora A/B/C antibody

Human Cervix stained with anti-Aurora A/B/C antibody

Human Tonsil stained with anti-Aurora A/B/C antibody

Human Placenta stained with anti-Aurora A/B/C antibody

Human Uterus stained with anti-Aurora A/B/C antibody

Human Cervix stained with anti-Aurora A/B/C antibody

Human Tonsil stained with anti-Aurora A/B/C antibody

Human Placenta stained with anti-Aurora A/B/C antibody

Human Skin stained with anti-Aurora A/B/C antibody

Human Skin SCCa stained with anti-Aurora A/B/C antibody

Human Skin stained with anti-Aurora A/B/C antibody

Human Skin SCCa stained with anti-Aurora A/B/C antibody


Product Details:


Technology

Rabbit Monoclonal

Clone Name

SP201

Application

IHC-P, FACS

Species Reactivity

 

   Tested

Hu

   Predicted by homology

Bv, Fg, Pg, Rt

Isotype

Rabbit IgG

Immunogen

Synthetic peptide near the C-terminus of human Aurora kinase A, B, and C proteins.

Cellular Localization

Cytoplasm, Nucleus

Control Tissue

Human Prostate Carcinoma

Regulatory Rating

Research Use Only (RUO)

Entrez

6790

Storage Requirement

2-8°C

Target Molecular Weight

48 kDa (A), 40kDa (B), 35kDa (C)

Formulation

Refer to Data Sheet

Product No: 07068654001
Product No: 07068689001

Rabbit Anti-Human Aurora Kinase A/B/C Monoclonal Antibody (Clone SP201)

Instructions for Use (PDF, 61.87 KB)
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